DAMAGING CARDIAC GENE VARIANTS DETERMINE RESPONSE TO LVAD THERAPY
نویسندگان
چکیده
منابع مشابه
Estimated prevalence of potentially damaging variants in the leptin gene
BACKGROUND Mutations in the leptin gene (LEP) can alter the secretion or interaction of leptin with its receptor, leading to extreme early-onset obesity. The purpose of this work was to estimate the prevalence of heterozygous and homozygous mutations in the leptin gene with the help of the Exome Aggregation Consortium (ExAC) database ( http://exac.broadinstitute.org/about ). RESULTS The ExAC ...
متن کاملCardiac sympathetic reserve and response to cardiac resynchronization therapy.
BACKGROUND The objective of the present study was to investigate the effect of cardiac resynchronization therapy (CRT) on cardiac autonomic function. METHODS AND RESULTS This prospective study included 45 consecutive patients with heart failure who received CRT devices with defibrillator and 20 age-matched, healthy control subjects. At baseline and 3 months and 6 months after CRT, we assessed...
متن کاملIdentification of genetic variants associated with response to statin therapy.
OBJECTIVE The purpose of this study was to test the association between polymorphisms in genes involved in either LDL cholesterol (LDL-C) metabolism or statin pharmacokinetics and LDL-C reduction with statins. METHODS AND RESULTS 49 tagging and candidate polymorphisms in 9 genes were genotyped in 1507 post-ACS subjects randomized to atorvastatin or pravastatin. Two polymorphisms (rs7412, rs42...
متن کاملNeutrophil-to-lymphocyte ratio predicts response to cardiac resynchronization therapy
BACKGROUND Neutrophil-to-lymphocyte (N/L) ratio has been associated with adverse outcomes in patients with acute coronary syndromes and increased risk for long-term mortality in patients with acute decompensated heart failure. We aimed to investigate the prognostic value of neutrophil-to-lymphocyte ratio on response to cardiac resynchronization therapy (CRT). MATERIAL AND METHODS Seventy cons...
متن کاملHow to predict response to cardiac resynchronization therapy?
Cardiac resynchronization therapy (CRT) is considered a major breakthrough in the treatment of patients with end-stage heart failure. Initial studies demonstrated an acute improvement in haemodynamics immediately after CRT, whereas a large number of studies with midterm follow-up (6 months to 1 year) demonstrated an improvement in heart failure symptoms, quality-of-life score, exercise capacity...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2015
ISSN: 0735-1097
DOI: 10.1016/s0735-1097(15)60891-9